Indicators 2018-2022
Table 1: Perinatal Mortality Associated with Congenital Anomalies in EUROCAT Full Member Registries (n=291), 2018-2022, by Type of Anomaly
Description2 | Breakdown by anomaly subgroup (as a % of all FDs) | Breakdown by anomaly subgroup (as a % of all Early Neonatal Deaths) | Prevalence of FD per 1,000 births | Prevalence of Early Neonatal Deaths per 1,000 births | Perinatal Mortality per 1,000 births3 |
---|---|---|---|---|---|
All anomalies | 100 | 100 | 0.56 | 0.41 | 0.96 |
All anomalies excluding genetic conditions | 58.3 | 71.2 | 0.32 | 0.29 | 0.61 |
Nervous system anomalies | 12.4 | 13.8 | 0.07 | 0.06 | 0.13 |
Neural tube defects | 5.2 | 6.6 | 0.03 | 0.03 | 0.06 |
Congenital heart defects | 16.8 | 27.1 | 0.09 | 0.11 | 0.20 |
Severe congenital heart defects | 9.5 | 16.4 | 0.05 | 0.07 | 0.12 |
Ventricular septal defect | 5.3 | 6.8 | 0.03 | 0.03 | 0.06 |
Hypoplastic left heart (HLH/HLHS) | 1.0 | 5.4 | 0.01 | 0.02 | 0.03 |
Gastro-intestinal anomalies | 5.9 | 16.3 | 0.03 | 0.07 | 0.10 |
Diaphragmatic hernia | 1.1 | 8.2 | 0.01 | 0.03 | 0.04 |
Congenital anomalies of kidney and urinary tract (CAKUT) | 11.0 | 18.4 | 0.06 | 0.08 | 0.14 |
Multicystic renal dysplasia | 1.8 | 5.1 | 0.01 | 0.02 | 0.03 |
Limb anomalies | 13.9 | 7.9 | 0.08 | 0.03 | 0.11 |
Club foot – talipes equinovarus | 7.8 | 3.3 | 0.04 | 0.01 | 0.06 |
Genetic disorders | 41.7 | 28.8 | 0.23 | 0.12 | 0.35 |
Down Syndrome / trisomy 21 | 11.3 | 3.0 | 0.06 | 0.01 | 0.07 |
Edwards syndrome / trisomy 18 | 9.1 | 6.5 | 0.05 | 0.03 | 0.08 |
FD=Fetal deaths from 20 weeks; early neonatal deaths=liveborns that died within the 1st week
Breakdown percentages are rounded to 1 decimal place. Prevalence rates are rounded to 2 decimal places.
1 Hainaut, Funen, Paris, Tuscany, Northern Netherlands, Vaud, Malta, Antwerp, Saxony-Anhalt, Styria, Cork & Kerry, Wales, Auvergne, OMNI-Net, Isle de Reunion, Thames Valley, Wessex, East Midlands & South Yorkshire, Northern England, French West Indies, South West England, Valencian Region, Brittany, Pleven, West Midlands, Yorkshire & Humber, North West England, Metropolitan Area Milan, Trento
2 Only subgroups contributing to at least 5% of early neonatal deaths or fetal deaths are shown.
3 Perinatal mortality is the sum of fetal deaths + early neonatal deaths.
Table 2: Fetal Death, Early Neonatal Death & Perinatal Mortality Associated with Congenital Anomalies per Country, 2018-2022, EUROCAT Full Member Registries (n=29)
Country | Prevalence of FD per 1,000 births | Prevalence of Early Neonatal Deaths per 1,000 births | Perinatal Mortality per 1,000 births1 |
---|---|---|---|
Austria (Styria) | 0.24 | 0.31 | 0.54 |
Belgium (Antwerp, Hainaut) | 0.51 | 0.25 | 0.76 |
Bulgaria (Pleven) | 0.87 | 0.87 | 1.74 |
Denmark (Funen) | 0.13 | 0.30 | 0.43 |
France (Paris, Isle de Reunion, French West Indies, Brittany, Auvergne) | 0.60 | 0.51 | 1.11 |
Germany (Saxony-Anhalt) | 0.36 | 0.44 | 0.80 |
Ireland (Cork & Kerry) | 1.28 | 0.89 | 2.17 |
Italy (Tuscany, Metropolitan Area Milan, Trento) | 0.19 | 0.12 | 0.31 |
Malta (Malta) | 0.31 | 1.34 | 1.65 |
Netherlands (N Netherlands) | 0.46 | 0.28 | 0.74 |
Spain (Valencian Region) | 0.51 | 0.24 | 0.75 |
Switzerland (Vaud) | 0.42 | 0.23 | 0.65 |
Ukraine (OMNI-Net) | 0.48 | 0.53 | 1.01 |
UK (N England, Thames Valley, E Mid & S York, Wales, Wessex, SW England, West Midlands, Yorkshire & Humber, NW England) | 0.63 | 0.44 | 1.07 |
EUROCAT total | 0.56 | 0.41 | 0.96 |
FD=Fetal deaths from 20 weeks; early neonatal deaths=liveborns that died within the 1st week
All figures are rounded to 2 decimal places.
1Perinatal mortality is the sum of fetal deaths + early neonatal deaths.
Table 3: Rate of Terminations of Pregnancy for Fetal Anomaly Following Prenatal Diagnosis (TOPFA) and Rates of Perinatal Deaths per 1,000 Births by Country, 2018-2022, EUROCAT Full Member Registries (n=29)
Country | Prevalence TOPFA <20 Weeks per 1,000 Births | Prevalence TOPFA 20+ Weeks per 1,000 Births | Total Prevalence TOPFA per 1,000 Births | Perinatal Mortality per 1,000 births1 | Perinatal Mortality + TOPFA per 1,000 births2 |
---|---|---|---|---|---|
Austria (Styria) | 2.39 | 1.34 | 3.77 | 0.54 | 4.31 |
Belgium (Antwerp, Hainaut) | 3.08 | 1.56 | 4.64 | 0.76 | 5.40 |
Bulgaria (Pleven) | 2.80 | 4.15 | 6.95 | 1.74 | 8.69 |
Denmark (Funen) | 5.21 | 2.65 | 7.86 | 0.43 | 8.29 |
France (Paris, Isle de Reunion, French West Indies, Brittany, Auvergne) | 5.01 | 3.34 | 8.35 | 1.11 | 9.47 |
Germany (Saxony-Anhalt) | 2.32 | 1.62 | 3.96 | 0.80 | 4.76 |
Ireland (Cork & Kerry) | 1.75 | 1.48 | 3.23 | 2.17 | 5.40 |
Italy (Tuscany, Metropolitan Area Milan, Trento) | 5.39 | 1.78 | 7.17 | 0.31 | 7.49 |
Malta (Malta) | 0.00 | 0.00 | 0.00 | 1.65 | 1.65 |
Netherlands (N Netherlands) | 3.49 | 2.42 | 5.97 | 0.74 | 6.71 |
Spain (Valencian Region) | 4.59 | 2.32 | 6.90 | 0.75 | 7.65 |
Switzerland (Vaud) | 6.22 | 1.76 | 7.98 | 0.65 | 8.62 |
Ukraine (OMNI-Net) | 1.98 | 1.49 | 3.48 | 1.01 | 4.49 |
UK (N England, Thames Valley, E Mid & S York, Wales, Wessex, SW England, West Midlands, Yorkshire & Humber, NW England) | 3.58 | 1.98 | 5.55 | 1.07 | 6.62 |
EUROCAT total | 3.85 | 2.12 | 6.07 | 0.96 | 7.04 |
All figures are rounded to 2 decimal places.
1Perinatal mortality is the sum of fetal deaths + early neonatal deaths.
2 Perinatal mortality+TOPFA is the sum of the previous 2 columns.
Indicators 2015-2019
Table 1: Perinatal Mortality Associated with Congenital Anomalies in EUROCAT Full Member Registries (n=331), 2015-2019, by Type of Anomaly
Description2 | Breakdown by anomaly subgroup (as a % of all FDs) | Breakdown by anomaly subgroup (as a % of all Early Neonatal Deaths) | Prevalence of FD per 1,000 births | Prevalence of Early Neonatal Deaths per 1,000 births | Perinatal Mortality per 1,000 births3 |
---|---|---|---|---|---|
All anomalies | 100 | 100 | 0.52 | 0.42 | 0.94 |
All anomalies excluding genetic conditions | 63.0 | 75.2 | 0.33 | 0.32 | 0.64 |
Nervous system anomalies | 13.3 | 12.8 | 0.07 | 0.05 | 0.12 |
Neural tube defects | 5.8 | 6.2 | 0.03 | 0.03 | 0.06 |
Congenital heart defects | 20.0 | 28.2 | 0.10 | 0.12 | 0.22 |
Severe congenital heart defects | 11.3 | 16.5 | 0.06 | 0.07 | 0.13 |
Ventricular septal defect | 6.6 | 7.5 | 0.03 | 0.03 | 0.07 |
Gastro-intestinal anomalies | 7.7 | 17.6 | 0.04 | 0.07 | 0.11 |
Diaphragmatic hernia | 1.3 | 8.9 | 0.01 | 0.04 | 0.04 |
Congenital anomalies of kidney and urinary tract (CAKUT) | 10.3 | 18.8 | 0.05 | 0.08 | 0.13 |
Bilateral renal agenesis including Potter sequence | 1.3 | 5.2 | 0.01 | 0.02 | 0.03 |
Multicystic renal dysplasia | 1.8 | 5.1 | 0.01 | 0.02 | 0.03 |
Limb anomalies | 13.8 | 8.8 | 0.07 | 0.04 | 0.11 |
Club foot – talipes equinovarus | 7.6 | 3.0 | 0.04 | 0.01 | 0.05 |
Genetic disorders | 37.0 | 24.8 | 0.19 | 0.10 | 0.30 |
Down Syndrome / trisomy 21 | 9.8 | 2.2 | 0.05 | 0.01 | 0.06 |
Edwards syndrome / trisomy 18 | 8.4 | 5.4 | 0.04 | 0.02 | 0.07 |
FD=Fetal deaths from 20 weeks; early neonatal deaths=liveborns that died within the 1st week
Breakdown percentages are rounded to 1 decimal place. Prevalence rates are rounded to 2 decimal places.
1 Hainaut, Funen, Paris, Tuscany, Northern Netherlands, Emilia Romagna, Vaud, Zagreb, Malta, Antwerp, Saxony-Anhalt, Styria, Cork & Kerry, Wales, Norway, Auvergne, OMNI-Net, Isle de Reunion, Thames Valley, Wessex, East Midlands & South Yorkshire, Northern England, French West Indies, South West England, Valencian Region, Brittany, Pleven, West Midlands, Navarra, Yorkshire & Humber, ATS Valpadana, Milan Area, Trento
2 Only subgroups contributing to at least 5% of early neonatal deaths or fetal deaths are shown.
3 Perinatal mortality is the sum of fetal deaths + early neonatal deaths.
Table 2: Fetal Death, Early Neonatal Death & Perinatal Mortality Associated with Congenital Anomalies per Country, 2015-2019, EUROCAT Full Member Registries (n=33)
Country | Prevalence of FD per 1,000 births | Prevalence of Early Neonatal Deaths per 1,000 births | Perinatal Mortality per 1,000 births1 |
---|---|---|---|
Austria (Styria) | 0.41 | 0.27 | 0.68 |
Belgium (Antwerp, Hainaut) | 0.35 | 0.38 | 0.73 |
Bulgaria (Pleven) | 1.00 | 1.28 | 2.28 |
Croatia (Zagreb) | 0.34 | 0.49 | 0.83 |
Denmark (Funen) | 0.21 | 0.21 | 0.43 |
France (Paris, Isle de Reunion, French West Indies, Auvergne, Brittany) | 0.55 | 0.60 | 1.15 |
Germany (Saxony-Anhalt) | 0.35 | 0.40 | 0.75 |
Ireland (Cork & Kerry) | 1.00 | 1.04 | 2.04 |
Italy (Tuscany, Emilia Romagna, ATS Valpadana, Metropolitan Area Milan, Trento) | 0.16 | 0.13 | 0.29 |
Malta (Malta) | 0.4 | 1.03 | 1.43 |
Netherlands (N Netherlands) | 0.55 | 0.29 | 0.84 |
Norway (Norway) | 0.31 | 0.39 | 0.70 |
Spain (Valencian Region, Navarra) | 0.45 | 0.31 | 0.76 |
Switzerland (Vaud) | 0.25 | 0.39 | 0.65 |
Ukraine (OMNI-Net) | 0.51 | 0.54 | 1.04 |
UK (N England, Thames Valley, E Mid & S York, Wales, Wessex, SW England, West Midlands, Yorkshire & Humber) | 0.69 | 0.45 | 1.15 |
EUROCAT total | 0.52 | 0.42 | 0.94 |
FD=Fetal deaths from 20 weeks; early neonatal deaths=liveborns that died within the 1st week
All figures are rounded to 2 decimal places.
1Perinatal mortality is the sum of fetal deaths + early neonatal deaths.
Table 3: Rate of Terminations of Pregnancy for Fetal Anomaly Following Prenatal Diagnosis (TOPFA) and Rates of Perinatal Deaths per 1,000 Births by Country, 2015-2019, EUROCAT Full Member Registries (n=33)
Country | Prevalence TOPFA <20 Weeks per 1,000 Births | Prevalence TOPFA 20+ Weeks per 1,000 Births | Total Prevalence TOPFA per 1,000 Births | Perinatal Mortality per 1,000 births1 | Perinatal Mortality + TOPFA per 1,000 births2 |
---|---|---|---|---|---|
Austria (Styria) | 2.79 | 1.31 | 4.31 | 0.68 | 4.99 |
Belgium (Antwerp, Hainaut) | 3.03 | 1.55 | 4.66 | 0.73 | 5.39 |
Bulgaria (Pleven) | 2.19 | 3.92 | 6.11 | 2.28 | 8.39 |
Croatia (Zagreb) | 1.54 | 0.64 | 2.22 | 0.83 | 3.05 |
Denmark (Funen) | 5.53 | 2.32 | 7.85 | 0.43 | 8.28 |
France (Paris, Isle de Reunion, French West Indies, Auvergne, Brittany) | 4.75 | 3.45 | 8.21 | 1.15 | 9.36 |
Germany (Saxony-Anhalt) | 2.63 | 1.53 | 4.18 | 0.75 | 4.93 |
Ireland (Cork & Kerry) | 1.09 | 0.88 | 2.20 | 2.04 | 4.24 |
Italy (Tuscany, Emilia Romagna, ATS Valpadana, Metropolitan Area Milan, Trento) | 4.03 | 1.74 | 5.89 | 0.29 | 6.18 |
Malta (Malta) | 0.00 | 0.00 | 0.00 | 1.43 | 1.43 |
Netherlands (N Netherlands) | 2.81 | 2.46 | 5.28 | 0.84 | 6.12 |
Norway (Norway) | 3.43 | 1.01 | 4.44 | 0.70 | 5.15 |
Spain (Valencian Region, Navarra) | 4.67 | 2.77 | 7.45 | 0.76 | 8.21 |
Switzerland (Vaud) | 5.97 | 2.08 | 8.05 | 0.65 | 8.69 |
Ukraine (OMNI-Net) | 2.18 | 1.66 | 3.84 | 1.04 | 4.88 |
UK (N England, Thames Valley, E Mid & S York, Wales, Wessex, SW England, West Midlands, Yorkshire & Humber) | 3.58 | 1.96 | 5.69 | 1.15 | 6.84 |
EUROCAT total | 3.69 | 2.05 | 5.83 | 0.94 | 6.77 |
All figures are rounded to 2 decimal places.
1 Perinatal mortality is the sum of fetal deaths + early neonatal deaths.
2 Perinatal mortality+TOPFA is the sum of the previous 2 columns.
Indicators 2010-2014
Table 1: Perinatal Mortality Associated with Congenital Anomalies in EUROCAT Full Member Registries (n=261), 2010-2014, by Type of Anomaly
Description2 | Breakdown by anomaly subgroup (as a % of all FDs) | Breakdown by anomaly subgroup (as a % of all Early Neonatal Deaths) | Prevalence of FD per 1,000 births | Prevalence of Early Neonatal Deaths per 1,000 births | Perinatal Mortality per 1,000 births3 |
---|---|---|---|---|---|
All anomalies | 100 | 100 | 0.45 | 0.43 | 0.88 |
All anomalies excluding genetic conditions | 62.6 | 76 | 0.28 | 0.33 | 0.61 |
Nervous system anomalies | 16.3 | 15.2 | 0.07 | 0.07 | 0.14 |
Neural tube defects | 7.3 | 5.9 | 0.03 | 0.03 | 0.06 |
Anencephaly and similar | 5.2 | 3.5 | 0.02 | 0.02 | 0.04 |
Congenital heart defects | 18.2 | 28.1 | 0.08 | 0.12 | 0.20 |
Severe congenital heart defects | 10.7 | 18.1 | 0.05 | 0.08 | 0.13 |
Ventricular septal defect | 5.6 | 7.2 | 0.03 | 0.03 | 0.06 |
Hypoplastic left heart (HLH/HLHS) | 1.8 | 6.6 | 0.01 | 0.03 | 0.04 |
Gastro-intestinal anomalies | 7.6 | 17.3 | 0.03 | 0.07 | 0.11 |
Diaphragmatic hernia | 1.4 | 9.6 | 0.01 | 0.04 | 0.05 |
Congenital anomalies of kidney and urinary tracks (CAKUT) | 10.8 | 17.9 | 0.05 | 0.08 | 0.13 |
Limb anomalies | 9.6 | 7.2 | 0.04 | 0.03 | 0.07 |
Genetic disorders | 37.4 | 24 | 0.17 | 0.10 | 0.27 |
Down Syndrome / trisomy 21 | 12.0 | 2.3 | 0.05 | 0.01 | 0.06 |
Edwards syndrome / trisomy 18 | 10.0 | 6.7 | 0.05 | 0.03 | 0.07 |
FD=Fetal deaths from 20 weeks of gestation; early neonatal deaths=liveborns that died within the 1st week
Breakdown percentages are rounded to 1 decimal place. Prevalence rates are rounded to 2 decimal places.
1 Hainaut, Funen, Paris, Tuscany, Northern Netherlands, Emilia Romagna, Vaud, Zagreb, Malta, Antwerp, Basque country, Saxony-Anhalt, Styria, Cork & Kerry, Wales, Norway, OMNI-Net, Isle de Reunion, Thames Valley, Wessex, Northern England, French West Indies, Valencian Region, Brittany, Pleven, ATS Valpadana
2 Only subgroups contributing to at least 5% of early neonatal deaths or fetal deaths are shown.
3 Perinatal mortality is the sum of fetal deaths + early neonatal deaths.
Table 2: Fetal Death, Early Neonatal Death & Perinatal Mortality Associated with Congenital Anomalies per Country, 2010-2014, EUROCAT Full Member Registries (n=26)
Country | Prevalence of FD per 1,000 births | Prevalence of Early Neonatal Deaths per 1,000 births | Perinatal Mortality per 1,000 births1 |
---|---|---|---|
Austria (Styria) | 0.23 | 0.33 | 0.56 |
Belgium (Antwerp, Hainaut) | 0.33 | 0.51 | 0.84 |
Bulgaria (Pleven) | 1.13 | 1.48 | 2.61 |
Croatia (Zagreb) | 0.41 | 0.12 | 0.53 |
Denmark (Funen) | 0.26 | 0.34 | 0.6 |
France (Paris, Isle de Reunion, French West Indies, Brittany) | 0.56 | 0.58 | 1.14 |
Germany (Saxony-Anhalt) | 0.34 | 0.29 | 0.63 |
Ireland (Cork & Kerry) | 1.03 | 1.27 | 2.29 |
Italy (Tuscany, Emilia Romagna, ATS Valpadana) | 0.17 | 0.18 | 0.35 |
Malta (Malta) | 1.00 | 1.47 | 2.47 |
Netherlands (N Netherlands) | 0.64 | 0.46 | 1.09 |
Norway (Norway) | 0.36 | 0.4 | 0.76 |
Spain (Basque Country, Valencian Region) | 0.19 | 0.27 | 0.46 |
Switzerland (Vaud) | 0.51 | 0.44 | 0.95 |
Ukraine (OMNI-Net) | 0.56 | 0.74 | 1.3 |
UK (N England, Thames Valley, Wales, Wessex) | 0.55 | 0.33 | 0.88 |
EUROCAT total | 0.45 | 0.43 | 0.88 |
FD=Fetal deaths from 20 weeks; early neonatal deaths=liveborns that died within the 1st week
All figures are rounded to 2 decimal places.
1Perinatal mortality is the sum of fetal deaths + early neonatal deaths.
Table 3: Rate of Terminations of Pregnancy for Fetal Anomaly Following Prenatal Diagnosis (TOPFA) and Rates of Perinatal Deaths per 1,000 Births by Country, 2010-2014, EUROCAT Full Member Registries (n=26)
Country | Prevalence TOPFA <20 Weeks per 1,000 Births | Prevalence TOPFA 20+ Weeks per 1,000 Births | Total Prevalence TOPFA per 1,000 Births | Perinatal Mortality per 1,000 births1 | Perinatal Mortality + TOPFA per 1,000 births2 |
---|---|---|---|---|---|
Austria (Styria) | 2.74 | 1.52 | 4.30 | 0.56 | 4.86 |
Belgium (Antwerp, Hainaut) | 2.49 | 1.29 | 3.93 | 0.84 | 4.77 |
Bulgaria (Pleven) | 2.26 | 1.48 | 3.74 | 2.61 | 6.35 |
Croatia (Zagreb) | 1.42 | 0.53 | 1.99 | 0.53 | 2.52 |
Denmark (Funen) | 5.14 | 2.01 | 7.15 | 0.60 | 7.75 |
France (Paris, Isle de Reunion, French West Indies, Brittany) | 4.52 | 3.74 | 8.27 | 1.14 | 9.41 |
Germany (Saxony-Anhalt) | 2.36 | 1.17 | 3.54 | 0.63 | 4.18 |
Ireland (Cork & Kerry) | 0.72 | 0.26 | 1.39 | 2.29 | 3.68 |
Italy (Tuscany, Emilia Romagna, ATS Valpadana) | 3.32 | 1.31 | 4.70 | 0.35 | 5.05 |
Malta (Malta) | 0.00 | 0.00 | 0.00 | 2.47 | 2.47 |
Netherlands (N Netherlands) | 2.25 | 2.28 | 4.55 | 1.09 | 5.65 |
Norway (Norway) | 3.19 | 0.87 | 4.06 | 0.76 | 4.81 |
Spain (Basque Country, Valencian Region) | 3.97 | 2.14 | 6.20 | 0.46 | 6.66 |
Switzerland (Vaud) | 5.64 | 1.94 | 7.58 | 0.95 | 8.53 |
Ukraine (OMNI-Net) | 1.57 | 1.86 | 3.43 | 1.30 | 4.74 |
UK (N England, Thames Valley, Wales, Wessex) | 3.71 | 2.17 | 5.89 | 0.88 | 6.78 |
EUROCAT total | 3.34 | 1.94 | 5.32 | 0.88 | 6.21 |
All figures are rounded to 2 decimal places.
1 Perinatal mortality is the sum of fetal deaths + early neonatal deaths.
2 Perinatal mortality+TOPFA is the sum of the previous 2 columns.