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Indicators 2018-2022

Table 1: Perinatal Mortality Associated with Congenital Anomalies in EUROCAT Full Member Registries (n=291), 2018-2022, by Type of Anomaly

Description2 Breakdown by anomaly subgroup (as a % of all FDs) Breakdown by anomaly subgroup (as a % of all Early Neonatal Deaths) Prevalence of FD per 1,000 births Prevalence of Early Neonatal Deaths per 1,000 births Perinatal Mortality per 1,000 births3
All anomalies 100 100 0.56 0.41 0.96
All anomalies excluding genetic conditions 58.3 71.2 0.32 0.29 0.61
Nervous system anomalies 12.4 13.8 0.07 0.06 0.13
Neural tube defects 5.2 6.6 0.03 0.03 0.06
Congenital heart defects 16.8 27.1 0.09 0.11 0.20
Severe congenital heart defects 9.5 16.4 0.05 0.07 0.12
Ventricular septal defect 5.3 6.8 0.03 0.03 0.06
Hypoplastic left heart (HLH/HLHS) 1.0 5.4 0.01 0.02 0.03
Gastro-intestinal anomalies 5.9 16.3 0.03 0.07 0.10
Diaphragmatic hernia 1.1 8.2 0.01 0.03 0.04
Congenital anomalies of kidney and urinary tract (CAKUT) 11.0 18.4 0.06 0.08 0.14
Multicystic renal dysplasia 1.8 5.1 0.01 0.02 0.03
Limb anomalies 13.9 7.9 0.08 0.03 0.11
Club foot – talipes equinovarus 7.8 3.3 0.04 0.01 0.06
Genetic disorders 41.7 28.8 0.23 0.12 0.35
Down Syndrome / trisomy 21 11.3 3.0 0.06 0.01 0.07
Edwards syndrome / trisomy 18 9.1 6.5 0.05 0.03 0.08

FD=Fetal deaths from 20 weeks; early neonatal deaths=liveborns that died within the 1st week

Breakdown percentages are rounded to 1 decimal place. Prevalence rates are rounded to 2 decimal places.

1 Hainaut, Funen, Paris, Tuscany, Northern Netherlands, Vaud, Malta, Antwerp, Saxony-Anhalt, Styria, Cork & Kerry, Wales, Auvergne, OMNI-Net, Isle de Reunion, Thames Valley, Wessex, East Midlands & South Yorkshire, Northern England, French West Indies, South West England, Valencian Region, Brittany, Pleven, West Midlands, Yorkshire & Humber, North West England, Metropolitan Area Milan, Trento

2 Only subgroups contributing to at least 5% of early neonatal deaths or fetal deaths are shown.

3 Perinatal mortality is the sum of fetal deaths + early neonatal deaths.

Table 2: Fetal Death, Early Neonatal Death & Perinatal Mortality Associated with Congenital Anomalies per Country, 2018-2022, EUROCAT Full Member Registries (n=29)

Country Prevalence of FD per 1,000 births Prevalence of Early Neonatal Deaths per 1,000 births Perinatal Mortality per 1,000 births1
Austria (Styria) 0.24 0.31 0.54
Belgium (Antwerp, Hainaut) 0.51 0.25 0.76
Bulgaria (Pleven) 0.87 0.87 1.74
Denmark (Funen) 0.13 0.30 0.43
France (Paris, Isle de Reunion, French West Indies, Brittany, Auvergne) 0.60 0.51 1.11
Germany (Saxony-Anhalt) 0.36 0.44 0.80
Ireland (Cork & Kerry) 1.28 0.89 2.17
Italy (Tuscany, Metropolitan Area Milan, Trento) 0.19 0.12 0.31
Malta (Malta) 0.31 1.34 1.65
Netherlands (N Netherlands) 0.46 0.28 0.74
Spain (Valencian Region) 0.51 0.24 0.75
Switzerland (Vaud) 0.42 0.23 0.65
Ukraine (OMNI-Net) 0.48 0.53 1.01
UK (N England, Thames Valley, E Mid & S York, Wales, Wessex, SW England, West Midlands, Yorkshire & Humber, NW England) 0.63 0.44 1.07
EUROCAT total 0.56 0.41 0.96

FD=Fetal deaths from 20 weeks; early neonatal deaths=liveborns that died within the 1st week

All figures are rounded to 2 decimal places.

1Perinatal mortality is the sum of fetal deaths + early neonatal deaths.

Table 3: Rate of Terminations of Pregnancy for Fetal Anomaly Following Prenatal Diagnosis (TOPFA) and Rates of Perinatal Deaths per 1,000 Births by Country, 2018-2022, EUROCAT Full Member Registries (n=29)

Country Prevalence TOPFA <20 Weeks per 1,000 Births Prevalence TOPFA 20+ Weeks per 1,000 Births Total Prevalence TOPFA per 1,000 Births Perinatal Mortality per 1,000 births1 Perinatal Mortality + TOPFA per 1,000 births2
Austria (Styria) 2.39 1.34 3.77 0.54 4.31
Belgium (Antwerp, Hainaut) 3.08 1.56 4.64 0.76 5.40
Bulgaria (Pleven) 2.80 4.15 6.95 1.74 8.69
Denmark (Funen) 5.21 2.65 7.86 0.43 8.29
France (Paris, Isle de Reunion, French West Indies, Brittany, Auvergne) 5.01 3.34 8.35 1.11 9.47
Germany (Saxony-Anhalt) 2.32 1.62 3.96 0.80 4.76
Ireland (Cork & Kerry) 1.75 1.48 3.23 2.17 5.40
Italy (Tuscany, Metropolitan Area Milan, Trento) 5.39 1.78 7.17 0.31 7.49
Malta (Malta) 0.00 0.00 0.00 1.65 1.65
Netherlands (N Netherlands) 3.49 2.42 5.97 0.74 6.71
Spain (Valencian Region) 4.59 2.32 6.90 0.75 7.65
Switzerland (Vaud) 6.22 1.76 7.98 0.65 8.62
Ukraine (OMNI-Net) 1.98 1.49 3.48 1.01 4.49
UK (N England, Thames Valley, E Mid & S York, Wales, Wessex, SW England, West Midlands, Yorkshire & Humber, NW England) 3.58 1.98 5.55 1.07 6.62
EUROCAT total 3.85 2.12 6.07 0.96 7.04

All figures are rounded to 2 decimal places.

1Perinatal mortality is the sum of fetal deaths + early neonatal deaths.

2 Perinatal mortality+TOPFA is the sum of the previous 2 columns.

Indicators 2015-2019

Table 1: Perinatal Mortality Associated with Congenital Anomalies in EUROCAT Full Member Registries (n=331), 2015-2019, by Type of Anomaly

Description2 Breakdown by anomaly subgroup (as a % of all FDs) Breakdown by anomaly subgroup (as a % of all Early Neonatal Deaths) Prevalence of FD per 1,000 births Prevalence of Early Neonatal Deaths per 1,000 births Perinatal Mortality per 1,000 births3
All anomalies 100 100 0.52 0.42 0.94
All anomalies excluding genetic conditions 63.0 75.2 0.33 0.32 0.64
Nervous system anomalies 13.3 12.8 0.07 0.05 0.12
Neural tube defects 5.8 6.2 0.03 0.03 0.06
Congenital heart defects 20.0 28.2 0.10 0.12 0.22
Severe congenital heart defects 11.3 16.5 0.06 0.07 0.13
Ventricular septal defect 6.6 7.5 0.03 0.03 0.07
Gastro-intestinal anomalies 7.7 17.6 0.04 0.07 0.11
Diaphragmatic hernia 1.3 8.9 0.01 0.04 0.04
Congenital anomalies of kidney and urinary tract (CAKUT) 10.3 18.8 0.05 0.08 0.13
Bilateral renal agenesis including Potter sequence 1.3 5.2 0.01 0.02 0.03
Multicystic renal dysplasia 1.8 5.1 0.01 0.02 0.03
Limb anomalies 13.8 8.8 0.07 0.04 0.11
Club foot – talipes equinovarus 7.6 3.0 0.04 0.01 0.05
Genetic disorders 37.0 24.8 0.19 0.10 0.30
Down Syndrome / trisomy 21 9.8 2.2 0.05 0.01 0.06
Edwards syndrome / trisomy 18 8.4 5.4 0.04 0.02 0.07

FD=Fetal deaths from 20 weeks; early neonatal deaths=liveborns that died within the 1st week

Breakdown percentages are rounded to 1 decimal place. Prevalence rates are rounded to 2 decimal places.

1 Hainaut, Funen, Paris, Tuscany, Northern Netherlands, Emilia Romagna, Vaud, Zagreb, Malta, Antwerp, Saxony-Anhalt, Styria, Cork & Kerry, Wales, Norway, Auvergne, OMNI-Net, Isle de Reunion, Thames Valley, Wessex, East Midlands & South Yorkshire, Northern England, French West Indies, South West England, Valencian Region, Brittany, Pleven, West Midlands, Navarra, Yorkshire & Humber, ATS Valpadana, Milan Area, Trento

2 Only subgroups contributing to at least 5% of early neonatal deaths or fetal deaths are shown.

3 Perinatal mortality is the sum of fetal deaths + early neonatal deaths.

Table 2: Fetal Death, Early Neonatal Death & Perinatal Mortality Associated with Congenital Anomalies per Country, 2015-2019, EUROCAT Full Member Registries (n=33)

Country Prevalence of FD per 1,000 births Prevalence of Early Neonatal Deaths per 1,000 births Perinatal Mortality per 1,000 births1
Austria (Styria) 0.41 0.27 0.68
Belgium (Antwerp, Hainaut) 0.35 0.38 0.73
Bulgaria (Pleven) 1.00 1.28 2.28
Croatia (Zagreb) 0.34 0.49 0.83
Denmark (Funen) 0.21 0.21 0.43
France (Paris, Isle de Reunion, French West Indies, Auvergne, Brittany) 0.55 0.60 1.15
Germany (Saxony-Anhalt) 0.35 0.40 0.75
Ireland (Cork & Kerry) 1.00 1.04 2.04
Italy (Tuscany, Emilia Romagna, ATS Valpadana, Metropolitan Area Milan, Trento) 0.16 0.13 0.29
Malta (Malta) 0.4 1.03 1.43
Netherlands (N Netherlands) 0.55 0.29 0.84
Norway (Norway) 0.31 0.39 0.70
Spain (Valencian Region, Navarra) 0.45 0.31 0.76
Switzerland (Vaud) 0.25 0.39 0.65
Ukraine (OMNI-Net) 0.51 0.54 1.04
UK (N England, Thames Valley, E Mid & S York, Wales, Wessex, SW England, West Midlands, Yorkshire & Humber) 0.69 0.45 1.15
EUROCAT total 0.52 0.42 0.94

FD=Fetal deaths from 20 weeks; early neonatal deaths=liveborns that died within the 1st week

All figures are rounded to 2 decimal places.

1Perinatal mortality is the sum of fetal deaths + early neonatal deaths.

Table 3: Rate of Terminations of Pregnancy for Fetal Anomaly Following Prenatal Diagnosis (TOPFA) and Rates of Perinatal Deaths per 1,000 Births by Country, 2015-2019, EUROCAT Full Member Registries (n=33)

Country Prevalence TOPFA <20 Weeks per 1,000 Births Prevalence TOPFA 20+ Weeks per 1,000 Births Total Prevalence TOPFA per 1,000 Births Perinatal Mortality per 1,000 births1 Perinatal Mortality + TOPFA per 1,000 births2
Austria (Styria) 2.79 1.31 4.31 0.68 4.99
Belgium (Antwerp, Hainaut) 3.03 1.55 4.66 0.73 5.39
Bulgaria (Pleven) 2.19 3.92 6.11 2.28 8.39
Croatia (Zagreb) 1.54 0.64 2.22 0.83 3.05
Denmark (Funen) 5.53 2.32 7.85 0.43 8.28
France (Paris, Isle de Reunion, French West Indies, Auvergne, Brittany) 4.75 3.45 8.21 1.15 9.36
Germany (Saxony-Anhalt) 2.63 1.53 4.18 0.75 4.93
Ireland (Cork & Kerry) 1.09 0.88 2.20 2.04 4.24
Italy (Tuscany, Emilia Romagna, ATS Valpadana, Metropolitan Area Milan, Trento) 4.03 1.74 5.89 0.29 6.18
Malta (Malta) 0.00 0.00 0.00 1.43 1.43
Netherlands (N Netherlands) 2.81 2.46 5.28 0.84 6.12
Norway (Norway) 3.43 1.01 4.44 0.70 5.15
Spain (Valencian Region, Navarra) 4.67 2.77 7.45 0.76 8.21
Switzerland (Vaud) 5.97 2.08 8.05 0.65 8.69
Ukraine (OMNI-Net) 2.18 1.66 3.84 1.04 4.88
UK (N England, Thames Valley, E Mid & S York, Wales, Wessex, SW England, West Midlands, Yorkshire & Humber) 3.58 1.96 5.69 1.15 6.84
EUROCAT total 3.69 2.05 5.83 0.94 6.77

All figures are rounded to 2 decimal places.

1 Perinatal mortality is the sum of fetal deaths + early neonatal deaths.

2 Perinatal mortality+TOPFA is the sum of the previous 2 columns.

Indicators 2010-2014

Table 1: Perinatal Mortality Associated with Congenital Anomalies in EUROCAT Full Member Registries (n=261), 2010-2014, by Type of Anomaly

Description2 Breakdown by anomaly subgroup (as a % of all FDs) Breakdown by anomaly subgroup (as a % of all Early Neonatal Deaths) Prevalence of FD per 1,000 births Prevalence of Early Neonatal Deaths per 1,000 births Perinatal Mortality per 1,000 births3
All anomalies 100 100 0.45 0.43 0.88
All anomalies excluding genetic conditions 62.6 76 0.28 0.33 0.61
Nervous system anomalies 16.3 15.2 0.07 0.07 0.14
Neural tube defects 7.3 5.9 0.03 0.03 0.06
Anencephaly and similar 5.2 3.5 0.02 0.02 0.04
Congenital heart defects 18.2 28.1 0.08 0.12 0.20
Severe congenital heart defects 10.7 18.1 0.05 0.08 0.13
Ventricular septal defect 5.6 7.2 0.03 0.03 0.06
Hypoplastic left heart (HLH/HLHS) 1.8 6.6 0.01 0.03 0.04
Gastro-intestinal anomalies 7.6 17.3 0.03 0.07 0.11
Diaphragmatic hernia 1.4 9.6 0.01 0.04 0.05
Congenital anomalies of kidney and urinary tracks (CAKUT) 10.8 17.9 0.05 0.08 0.13
Limb anomalies 9.6 7.2 0.04 0.03 0.07
Genetic disorders 37.4 24 0.17 0.10 0.27
Down Syndrome / trisomy 21 12.0 2.3 0.05 0.01 0.06
Edwards syndrome / trisomy 18 10.0 6.7 0.05 0.03 0.07

FD=Fetal deaths from 20 weeks of gestation; early neonatal deaths=liveborns that died within the 1st week

Breakdown percentages are rounded to 1 decimal place. Prevalence rates are rounded to 2 decimal places.

1 Hainaut, Funen, Paris, Tuscany, Northern Netherlands, Emilia Romagna, Vaud, Zagreb, Malta, Antwerp, Basque country, Saxony-Anhalt, Styria, Cork & Kerry, Wales, Norway, OMNI-Net, Isle de Reunion, Thames Valley, Wessex, Northern England, French West Indies, Valencian Region, Brittany, Pleven, ATS Valpadana

2 Only subgroups contributing to at least 5% of early neonatal deaths or fetal deaths are shown.

3 Perinatal mortality is the sum of fetal deaths + early neonatal deaths.

Table 2: Fetal Death, Early Neonatal Death & Perinatal Mortality Associated with Congenital Anomalies per Country, 2010-2014, EUROCAT Full Member Registries (n=26)

Country Prevalence of FD per 1,000 births Prevalence of Early Neonatal Deaths per 1,000 births Perinatal Mortality per 1,000 births1
Austria (Styria) 0.23 0.33 0.56
Belgium (Antwerp, Hainaut) 0.33 0.51 0.84
Bulgaria (Pleven) 1.13 1.48 2.61
Croatia (Zagreb) 0.41 0.12 0.53
Denmark (Funen) 0.26 0.34 0.6
France (Paris, Isle de Reunion, French West Indies, Brittany) 0.56 0.58 1.14
Germany (Saxony-Anhalt) 0.34 0.29 0.63
Ireland (Cork & Kerry) 1.03 1.27 2.29
Italy (Tuscany, Emilia Romagna, ATS Valpadana) 0.17 0.18 0.35
Malta (Malta) 1.00 1.47 2.47
Netherlands (N Netherlands) 0.64 0.46 1.09
Norway (Norway) 0.36 0.4 0.76
Spain (Basque Country, Valencian Region) 0.19 0.27 0.46
Switzerland (Vaud) 0.51 0.44 0.95
Ukraine (OMNI-Net) 0.56 0.74 1.3
UK (N England, Thames Valley, Wales, Wessex) 0.55 0.33 0.88
EUROCAT total 0.45 0.43 0.88

FD=Fetal deaths from 20 weeks; early neonatal deaths=liveborns that died within the 1st week

All figures are rounded to 2 decimal places.

1Perinatal mortality is the sum of fetal deaths + early neonatal deaths.

Table 3: Rate of Terminations of Pregnancy for Fetal Anomaly Following Prenatal Diagnosis (TOPFA) and Rates of Perinatal Deaths per 1,000 Births by Country, 2010-2014, EUROCAT Full Member Registries (n=26)

Country Prevalence TOPFA <20 Weeks per 1,000 Births Prevalence TOPFA 20+ Weeks per 1,000 Births Total Prevalence TOPFA per 1,000 Births Perinatal Mortality per 1,000 births1 Perinatal Mortality + TOPFA per 1,000 births2
Austria (Styria) 2.74 1.52 4.30 0.56 4.86
Belgium (Antwerp, Hainaut) 2.49 1.29 3.93 0.84 4.77
Bulgaria (Pleven) 2.26 1.48 3.74 2.61 6.35
Croatia (Zagreb) 1.42 0.53 1.99 0.53 2.52
Denmark (Funen) 5.14 2.01 7.15 0.60 7.75
France (Paris, Isle de Reunion, French West Indies, Brittany) 4.52 3.74 8.27 1.14 9.41
Germany (Saxony-Anhalt) 2.36 1.17 3.54 0.63 4.18
Ireland (Cork & Kerry) 0.72 0.26 1.39 2.29 3.68
Italy (Tuscany, Emilia Romagna, ATS Valpadana) 3.32 1.31 4.70 0.35 5.05
Malta (Malta) 0.00 0.00 0.00 2.47 2.47
Netherlands (N Netherlands) 2.25 2.28 4.55 1.09 5.65
Norway (Norway) 3.19 0.87 4.06 0.76 4.81
Spain (Basque Country, Valencian Region) 3.97 2.14 6.20 0.46 6.66
Switzerland (Vaud) 5.64 1.94 7.58 0.95 8.53
Ukraine (OMNI-Net) 1.57 1.86 3.43 1.30 4.74
UK (N England, Thames Valley, Wales, Wessex) 3.71 2.17 5.89 0.88 6.78
EUROCAT total 3.34 1.94 5.32 0.88 6.21

All figures are rounded to 2 decimal places.

1 Perinatal mortality is the sum of fetal deaths + early neonatal deaths.

2 Perinatal mortality+TOPFA is the sum of the previous 2 columns.